The immunodeficient pig serves as an excellent model for both primary and secondary immune deficiencies in humans. Oral immunoglobulin has excellent prospects as a companion therapy to intravenous immunoglobulin because oral Ig will help support the immune system in the gut and reduces diarrhea. The objective of support with oral immunoglobulin is to increase mucosal immunoglobulin levels to lower incidence of chronic diarrhea. The likelihood of improving quality of life is very high.

The lack of immune function initiated by HIV results in frequent problems with gastrointestinal opportunistic infections and diarrhea. In severe cases, the diarrhea can be life-threatening resulting in weight loss and loss of lean body mass. Supplementation with immunoglobulin should reduce the incidence of opportunistic infections and in addition, the possible immune sparing like effects of oral immunoglobulin supplementation may enable the body’s already over-burdened immune system to mobilize a greater level of it’s total immune assets in an attempt to overcome it’s primary infectious condition. It is hoped that supplementation with Immunoglobulin will enable individuals afflicted with HIV to achieve a higher level of wellness in their lives.

Young children are very vulnerable to both viral and bacterial infections because of the immaturity of the immune system. In addition, many children additionally suffer from HIV, malnutrition, transient hypogammaglobulinemia and other causes of secondary immune deficiencies. Viral infections, particularly rotavirus, are common and a condition for which there is no remedy. The viral-binding nature of immunoglobulin may both reduce incidence and shorten the recovery period of virus-based illnesses, particularly those affecting the gastrointestinal tract. Also, children have historically received immunoglobulin through breast milk so oral immunoglobulin supplementation is a very close parallel to the natural process of boosting immunity in children.

Immune responsiveness declines as people age. Studies of healthy centenarians have shown that they are able to maintain immune function to an older age than the general population. Since it is unknown as to how aging people can maintain or improve function, supplementation of antibodies is one means of conferring immunity without reliance on the immune system to function. People over the age of 70 often begin to lose weight, appetite and suffer from malnutrition so they may also suffer from a lack of immunity. Also, many elderly are also housed in long-term care, so they may also be exposed to organisms responsible for nosocomial infections on a regular basis. In addition, dropping levels of growth hormone, such as IGF-1, in the elderly creates classic age-related problems such as reduced lean body mass and bone density. Immunoglobulin Isolate from a specific bovine source nutrient is a natural source of IGF-1, containing much higher concentrations than other proteins. Also, circulating IGF-1 is affected by diet. IGF-1 levels are positively correlated with protein supplementation. Higher growth factor levels may in turn exert anti-aging benefits, which is delaying or improving age-related problems. Together, these circumstances support the use of immunoglobulin as a supportive nutritional therapy to humans as they age.

Nearly 30 million people in the US alone are affected by irritable bowel syndrome. Half of these individuals experience frequent problems with diarrhea. While a cause has not been identified, IBS is reported to be more common following gastrointestinal infections. Immunoglobulin supplementation may be very beneficial in reducing the responsiveness of the gut to changes in luminal content and reducing diarrhea.

Inflammatory bowel disease is a chronic inflammatory disorder of the gut that affects nearly 1 million people in the U.S. The disorder is an immunological condition characterized by high levels of inflammatory cytokine production. Three different groups of researchers have demonstrated that oral immunoglobulin supplementation reduces inflammatory cytokine production in animal models. In addition, one clinical study in Crohn’s disease patients reported that human immunoglobulin administered orally assists in maintaining remission. With the mode of action being consistent with the cause of symptoms, immunoglobulin supplementation has tremendous potential in alleviating the problems associated with this disorder.

Athletes don’t suffer from a disease but they have three needs where concentrated immunoglobulin supplementation may benefit from them: 1) Improve immunity as they prepare and travel to a competition; 2) A boost in growth factor levels; 3) Reduced inflammatory cytokine production. The gut is involved in partitioning the body’s resources. Increasing challenges in the gut will lead to resources (protein and energy) being directed to address the challenge rather than to muscle or bone. Since the gut is in a constant state of controlled inflammation, administering immunoglobulin can indirectly support the body’s use of its resources for productive functions, lean body mass. IGF-1, a growth factor that promotes protein synthesis, has also been shown to increase with the supplementation of an immunoglobulin source.

12 million people travel to developing countries and up to 30% develop diarrhea. E. coli, Campylobacter, Salmonella, and Cryptosporidia are the organisms responsible for the largest number of cases of traveler’s diarrhea. Travelers are often stressed and their immune systems are not prepared for the levels of exposure they will face. Immunoglobulin supplementation is one rapid method of broadening immunity and boosting the body’s defenses.

Stress lowers immune function and leads to increased susceptibility to illness. Also, a simple trip to a restaurant can cause illness as a result of poorly prepared food. Every person in the US will experience food-borne illness three times per year. Immunoglobulin supplementation may reduce the incidence of food-borne illness because of its concentration of antibodies against common food-born microbes.

Acute coronavirus infections result in tremendous increases in pro-inflammatory cytokine production. The dramatic increases in cytokines and increased sensitization of the immune system to endotoxin have been found to be important to the respiratory pathology of coronavirus infections. Our research group and others have found that the oral administration of immunoglobulin from a specific bovine source nutrient reduces basal pro-inflammatory cytokine production in both immunodeficient pig and healthy mice models. The effects on pro-inflammatory cytokine production explain the improvements in appetite and growth observed in previous animal studies. Most importantly, in models of recovery from both coronavirus infection and rotavirus infection, researchers have found reduced morbidity as measured by respiration rate, appetite, diarrhea, attitude and weight gain when animals were orally administered proteins from a specific bovine source nutrient following the challenge. In the calf model of coronavirus infections, the dose of immunoglobulin (16g per day) was intended to aid in the recovery of animals with an established infection. Therefore, the model utilized a high challenge dose in animals that were very young and susceptible to infection. The challenge dose of 1 x 10⁷ plaque-forming units of bovine coronavirus are many fold more than the low levels of coronavirus exposure that typically occurs in natural infection conditions in humans. The immunocompetency and immunological responsiveness of the host as well as the expected level of coronavirus exposure are important factors in determining an appropriate level of supplementation for prophylaxis or recovery in humans.

An extensive amount of recent scientific evidence supports the use of natural immunoglobulin as a means of providing a rapid boost in mucosal immunity which itself has numerous human health applications. In addition, new evidence is supportive of the oral use of immunoglobulin in modulating the immune response and reducing the symptoms associated opportunistic infections. Natural immunoglobulin is as safe for humans as the consumption of basic foods.  A specific bovine source nutrient has been evaluated for safety in young children and proprietary IG-MAXX has been available as a dietary supplement in the US for nearly four years without an adverse event report. The need for a product that can improve gut health and immunity are staggering when one considers the number of immune deficient people in the world.

These statements have not been evaluated by the Food & Drug Administration.  This product is not intended to diagnose, treat, cure or prevent any disease.